George M. Church, Ph.D.
We develop technology for reading and writing genomes. Four mutations can increase bacterial radiation resistance 100,000-fold. Is this generalizable to human cells? Low-gravity bone loss might be prevented in humans with increased bone density mutations (LRP5). Pain insensitive humans (SCN9A mutations) inspire developing regulatable variants. Combined with elimination of microbes (+ vaccines) could reduce payload needs of surgery and cleaning. What minimal biospheres suffice for recycling food and materials (including self-replicating manufacturing). Given diverse target environments, what is the minimal (relativistic) transport time to nearby stars of cells capable of making complex structures like radio transmitters?
Rogers JK, Guzman CD, Taylor ND, Raman S, Anderson K, Church GM (2015) Synthetic biosensors for precise gene control and real-time monitoring of metabolites. Nucleic Acids Research. PMID: 26152303
Church GM, Regis E (2012) Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves 288 pages. Basic Books, publisher.
Drukier A, Freese K, Spergel D, Cantor C, Church G, Sano T (2012) New Dark Matter Detectors using DNA for Nanometer Tracking ArXiv. 29-Jun-2012
Yaung SJ, Church GM, Wang HH (2013) Recent Progress in Engineering Human-associated Microbiomes. Methods Mol Biol. 2014;1151:3-25. PMID: 24838875